Health concerns Triclocarban

1 health concerns

1.1 personal care
1.2 endocrine disorders
1.3 allergies

health concerns
personal care

one study has investigated how triclocarban remains in human system after using bar of soap traces of triclocarban. analysis of urine samples human test subjects shows that, after triclocarban has undergone glucuronidation, oxidative metabolites less readily excreted triclocarban itself. same study performed topical treatments of triclocarban on rats and, analyzing urine , plasma levels, demonstrated triclocarban remain in organism s system.

endocrine disorders

triclocarban induces weak responses mediated aryl hydrocarbon, estrogen, , androgen receptors in vitro. has yet confirmed in vivo. in vitro, dihydrotestosterone-dependent activation of androgen receptor-responsive gene expression enhanced triclocarban 130%. triclocarban potent inhibitor of enzyme soluble epoxide hydrolase (seh) in vitro. additionally, triclocarban amplifies bioactivity of testosterone , other androgens. increased activity may have adverse implications reproductive health. triclocarban studies on rats exhibited increased size of specimens prostate glands. amplification of sex hormones promote growth of breast , prostate cancer.

while triclocarban causes endocrine disruption, chemical toxicity respect lethality low (ld50 >5000 mg/kg). rate of skin absorption low. repeated low-dose exposure, however, can cause endocrine disruption on time.

allergies

triclocarban causes irritation of lungs, eyes, , skin. canada , japan restrict content of triclocarban in cosmetics. triclocarban may cause sensitization aeroallergens , food.